Reducing Damage in Stroke
Purinergic Treatment in a Stroke Model Reduces Brain Lesion Size
The middle cerebral artery of mice was occluded for 1 hr and then released (MCAo model), and immediately followed with treatment by tail-vein injection. After 24 hrs, mouse brains were examined with viability dye TTC (red). 1A shows coronal brain slice from untreated mouse 24 hours with large area of necrotic tissue (green dashed outline). 1B shows brain from treated mouse at 24 hours with a significant reduction in lesion size. 1C shows histogram of average lesion size calculated from 4 mice per group.
Purinergic Treatment at 24 hours Post-Thrombosis Decreases the Size of Cortical Lesions
Mice were imaged at day 0 (pre-thrombosis) and at 24, 48 hours post-thrombosis. At 24 hours, mice were treated via tail vein injection. 2A displays summary of 5 control and 5 treated mice demonstrating significant improvement even at late intervention time points.