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Astrocyte Pharmaceuticals is currently investigating several programs for the potential treatment of acute ischemic stroke, TBI, concussion, and other injuries to the brain.

The company’s lead candidate program AST-004 is a novel small molecule candidate currently in human Phase II clinical trials with an intravenous injection formulation suitable for administration by emergency professionals. An oral “field” formulation of AST-004 for mild TBI and concussions, and for chronic administration for neurodegenerative diseases is in preclinical development.

Candidate

Indication

Preclinical

Phase 1

Phase 2

Phase 3

AST-004

Sports-Related Concussion (IV)

AST-004

Mild TBI (IV)

AST-004

Acute Ischemic Stroke

AST-004

Moderate-Severe TBI

AST-004

Concussion / Mild TBI (oral)

AST-004

Alzheimer’s Disease

AST-008

Pain / Migraine

undisclosed

Multiple CNS Indications

Candidate

Indication

Preclinical

Phase 1

Phase 2

Phase 3

AST-004

Concussion / Mild TBI

AST-004

Acute Ischemic Stroke

AST-004

Moderate-Severe TBI

AST-004

Alzheimer’s Disease

AST-008

Pain / Migraine

undisclosed

Multiple CNS Indications

Human Phase II patient clinical efficacy trials are in progress, and AST-004 is not yet approved by regulatory agencies such as the FDA for commercial use.