Dr. Liston is the Vice-President of Research at Astrocyte Pharmaceuticals. He has a 28-year record of research and innovation in the pharmaceutical industry, including senior research roles at Pfizer as Vice-President of Pharmacokinetics, Dynamics and Metabolism (PDM), and as Vice-President of Global ADME Technology. His pharmaceutical discovery and development experience in research, drug metabolism and PK/PD spans from early discovery projects to marketed products, and from laboratory operations to technology development. Dr. Liston managed the PDM efforts of groups in neuroscience and cardiovascular-metabolic disease, and has contributed to the preclinical and clinical advancement of >100 candidates across a broad range of therapeutic areas, including neuroscience, cardiovascular, infectious disease, inflammation, immunology, arthritis, allergy-respiratory and oncology. Additionally, Dr. Liston was the leader or key member in several scientific initiatives that transformed industrial pharmaceutical discovery and development, including the incorporation of high-throughput ADME/Toxicity screening, computational ADME, and prediction of human pharmacokinetics from preclinical in vitro and in vivo data.
Dr. Liston received his Ph.D. in Pharmacology from Vanderbilt University, where he focused on the structural elucidation and biological activity of novel human arachidonic acid metabolites and their role in physiology and disease.